Proposed Mechanism of Action
Liso-cel is an investigational chimeric antigen receptor (CAR) T cell therapy designed to target CD19,1,2 which is a surface glycoprotein expressed during normal B-cell development and maintained following malignant transformation of B cells.3-5 Liso-cel CAR T cells aim to target and kill non-Hodgkin lymphoma cells through a CAR construct that includes an anti-CD19 single-chain variable fragment (scFv) targeting domain for antigen specificity, a transmembrane domain, a 4-1BB costimulatory domain hypothesized to increase T-cell proliferation and persistence, and a CD3-zeta T-cell activation domain.1,2,6-9 The defined composition of liso-cel may limit product variability; however, the clinical significance of defined composition is unknown.1,10
Liso-Cel Proposed Mechanism of Action
Liso-cel, an investigational CAR T cell therapy, is proposed to target CD19-expressing cells in non-Hodgkin lymphoma
Liso-Cel by Disease State
Lisocabtagene maraleucel (liso-cel; JCAR017; CD19 CAR T) in Lymphoma
- Phase 1 Lymphoma Agressive large B-cell lymphoma: Relapsed/refractory
View Trials Investigating Liso-Cel in Lymphoma.Liso-Cel in Lymphoma
Rationale for Clinical Development
Preclinical studies have suggested that CAR T cells directed against CD19 demonstrate antitumor activity against lymphoma cells in mouse models.11,12
The safety and efficacy of agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.
- Abramson AS, et al. Oral presented at ASH 2017 [abstract 581].
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