Signaling is essential to the functioning of every cell. Cells communicate through extracellular signaling molecules, which are recognized by various receptors on their surface.1 Once receptors are activated by the binding of a ligand, a signaling cascade begins.1 These cascades are involved in numerous cellular processes, from growth and differentiation to apoptosis.1,2 Signaling pathways are intertwined, forming complex cellular signaling networks.1 Many pathways are altered in various types of cancers, leading to increased growth and even metastasis in many cases.2 Targeting members of these dysregulated pathways to attenuate the aberrant signaling cascade is a promising anticancer strategy.
- Giubellino A. In: Chatterjee M, Kashfi K, eds. Cell Signaling & Molecular Targets in Cancer. New York, NY: Springer: 2012:1-2.
- Bianco R, et al. Eur J Cancer. 2006;42:290-294. PMID: 16376541